Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors |
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| Authors: | María Luisa Pita-Lopez Inmaculada Gayoso Olga DelaRosa Javier G Casado Corona Alonso Elisa Muñoz-Gomariz Raquel Tarazona Rafael Solana |
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| Institution: | (1) Department of Cellular Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain;(2) Department of Physiology, Immunology Unit, University of Extremadura, Caceres, Spain;(3) Research Methodology Unit, H. U. Reina Sofia, Cordoba, Spain;(4) Molecular Biology and Immunology Unit, Department of Health and Well-being, South University Center, University of Guadalajara, Guzman City, Jalisco, Mexico |
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| Abstract: | Background Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus
(CMV) is one of the factors that affect functionality of T cells and the differentiation and large expansions of CMV pp65-specific
T cells have been associated with impaired responses to other immune challenges. Moreover, the presence of clonal expansions
of CMV-specific T cells may shrink the available repertoire for other antigens and contribute to the increased incidence of
infectious diseases in the elderly. In this study, we analyse the effect of ageing on the phenotype and frequency of CMV pp65-specific
CD8 T cell subsets according to the expression of CCR7, CD45RA, CD27, CD28, CD244 and CD85j. |
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