A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells |
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| Authors: | Henrik Stranneheim Lukas M Orre Janne Lehti? and Jenny Flygare |
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| Institution: | (1) Department of Gene Technology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden;(2) Karolinska Biomics Center, Karolinska University Hospital and Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden;(3) Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital Huddinge, F-46, SE-14186 Stockholm, Sweden |
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| Abstract: | Background B-cell lymphomas are thought to reflect different stages of B-cell maturation. Based on cytogenetics and molecular markers,
mantle cell lymphoma (MCL) is presumed to derive predominantly from na?ve, pre-germinal centre (pre-GC) B lymphocytes. The
aim of this study was to develop a method to investigate the similarity between MCL cells and different B-cell compartments
on a protein expression level. |
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