Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT. |
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| Authors: | I Kers J L Girardet G Gosselin C Perigaud J L Imbach J Stawinski |
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| Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden. |
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| Abstract: | The synthesis of some symmetrical phosphoramidate dimers of AZT is presented. The synthetic scheme includes the formation of the symmetrical H-phosphonate diester of AZT, followed by its conversion to several dinucleoside phosphoramidate analogues. The compounds were evaluated for their anti-retroviral activity. |
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