Suppression of tumourogenicity and overexpression of cell adhesion molecules in AK-5 cells transfected with wild-type p53 gene |
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Authors: | Ashok Khar B V V Pardhasaradhi |
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Institution: | (1) Centre for Cellular and Molecular Biology, 500007 Hyderabad, India |
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Abstract: | We have previously shown overexpression of p53 and rearrangement of the p53 gene in AK-5 tumour. In order to study the role
of p53 in AK-5 tumourogenicity, we introduced wild-type p53 in AK-5 cells. We have shown suppression of tumourogenicity in
AK-5 cells after transfixion with wt p53. In one of the transfected clones 3B4, there was complete loss of tumour forming
ability. Clone 3B4 also showed cellular aggregation which correlated well with the higher expression of cell adhesion molecules
like fibronectin and hyaluronectin. These observations demonstrate tumour suppression in AK-5 after introduction of wt p53. |
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Keywords: | wt p53 fibronectin hyaluronectin tumourogenicity |
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