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Interactome networks and human disease |
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| Authors: | Vidal Marc Cusick Michael E Barabási Albert-László |
| Institution: | 1 Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 2 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA 3 Center for Complex Network Research (CCNR) and Departments of Physics, Biology and Computer Science, Northeastern University, Boston, MA 02115, USA 4 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA |
| Abstract: | Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease. |
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