Metabolic connections during apoptotic cell engulfment |
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| Authors: | Han Claudia Z Ravichandran Kodi S |
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| Institution: | 1 Department of Microbiology, Immunology, and Cancer Biology, Carter Immunology Center and the Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908 |
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| Abstract: | Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment. |
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