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Autophagy and aging |
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| Authors: | Rubinsztein David C Mariño Guillermo Kroemer Guido |
| Institution: | 1 Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK 2 INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France 3 Metabolomics Platform, Institut Gustave Roussy, Pavillon de Recherche 1, 94805 Villejuif, France 4 University of Paris Sud, 94805 Villejuif, France 5 Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France 6 Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 20 rue Leblanc, 75015 Paris, France 7 Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France |
| Abstract: | Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin growth factor signaling, or the administration of rapamycin, resveratrol, or spermidine. Here, we discuss the probable cause and effect relationship between perturbed autophagy and aging, as well as possible molecular mechanisms that may mediate the anti-aging effects of autophagy. |
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