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Translational control by the eukaryotic ribosome |
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| Authors: | Topisirovic Ivan Sonenberg Nahum |
| Affiliation: | 1 Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada 2 Department of Oncology, McGill University, Montreal, Quebec H3T 1E2, Canada 3 Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada 4 Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada |
| Abstract: | The ribosome plays a universally conserved role in catalyzing protein synthesis. Kondrashov et?al. (2011) now provide evidence that the loss of function of ribosomal protein L38 in mice leads to a selective reduction in the translation of Hox mRNAs, thus suggesting that ribosomal proteins play a critical role during embryonic development. |
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