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Network news: innovations in 21st century systems biology |
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| Authors: | Arkin Adam P Schaffer David V |
| Affiliation: | 1 Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA 2 Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA 3 The Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA 4 Physical Biosciences Division, E.O. Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA |
| Abstract: | A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approaches bridge the gap between correlative analysis and mechanistic insights? |
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