The powerstroke and camshaft of the RIG-I antiviral RNA detection machine |
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| Authors: | O'Neill Luke A J Bowie Andrew G |
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| Institution: | 1 Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland |
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| Abstract: | The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et?al. (2011) and Luo et?al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response. |
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