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BET bromodomain inhibition as a therapeutic strategy to target c-Myc
Authors:Delmore Jake E  Issa Ghayas C  Lemieux Madeleine E  Rahl Peter B  Shi Junwei  Jacobs Hannah M  Kastritis Efstathios  Gilpatrick Timothy  Paranal Ronald M  Qi Jun  Chesi Marta  Schinzel Anna C  McKeown Michael R  Heffernan Timothy P  Vakoc Christopher R  Bergsagel P Leif  Ghobrial Irene M  Richardson Paul G  Young Richard A  Hahn William C  Anderson Kenneth C  Kung Andrew L  Bradner James E  Mitsiades Constantine S
Institution:1 Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
2 Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, 450 Brookline Avenue, Boston, MA 02215, USA
3 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
4 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
5 Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
6 Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
7 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
8 Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA
Abstract:
Keywords:
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