Leukocyte-migration inhibition in guinea pigs. I. Correlation with skin test reactivity and macrophage-migration inhibition. |
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| Authors: | P M Hoffman L E Spitler M Hsu |
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| Institution: | 3. Section of Immunology, Department of Medicine, and Cancer Research Institute, University of California School of Medicine, San Francisco, California 94143 U.S.A. |
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| Abstract: | Fifteen guinea pigs, immunized with one of three soluble antigens, repeatedly demonstrated inhibition of leukocyte migration and positive skin tests to the immunizing antigens. An additional five animals immunized with ovalbumin demonstrated inhibition of macrophage migration as well as direct and indirect inhibiton of leukocyte migration. Only one of fifteen animals demonstrated inhibition of leukocyte migration and none had a positive skin test with an antigen to which it had not been sensitized, indicating that the assay is antigen specific. |
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