Genomic analysis of Xenopus organizer function |
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Authors: | Andrew L Hufton Arunachalam Vinayagam Sándor Suhai Julie C Baker |
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Affiliation: | (1) Department of Genetics, Stanford University, Stanford, California, USA;(2) Department of Molecular Biophysics, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany |
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Abstract: | Background Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. The two primary activities of the organizer, BMP and Wnt inhibition, can regulate a spectrum of genes that pattern essentially all aspects of the embryo during gastrulation. As our knowledge of organizer signaling grows, it is imperative that we begin knitting together our gene-level knowledge into genome-level signaling models. The goal of this paper was to identify complete lists of genes regulated by different aspects of organizer signaling, thereby providing a deeper understanding of the genomic mechanisms that underlie these complex and fundamental signaling events. |
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