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Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment |
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| Authors: | Taka-aki Koshimizu Hiroyoshi Tsuchiya Yoko Fujiwara Akira Hirasawa Akio Fujimura |
| Institution: | a Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan b Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan c Department of Functional Genomics, Graduate School of Pharmaceutical Sciences, Himeji Dokkyo University, Hyogo 670-8524, Japan d Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan |
| Abstract: | |
| Keywords: | TG [Thr4-Gly7]-oxytocin Mpomeovt 1-deamino-2-O-methyl-tyrosyl-8-ornithine-1-(beta-mercapto-(beta beta-cyclopentamethylene)propionic acid)oxytocin Hsp90 heat shock protein 90 MOR μ-opioid receptor CREB cAMP response element-binding protein DMEM Dulbecco&rsquo s modified Eagle&rsquo s medium OT oxytocin ATII angiotensin II GAPDH glyceraldehyde-3-phosphate dehydrogenase ChIP chromatin immunoprecipitation |
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