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Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy |
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| Authors: | Xuhui Liu Givenchy Manzano David H. Lovett Hubert T. Kim |
| Affiliation: | a San Francisco Veterans Affairs Medical Center, Department of Veterans Affairs, 4150 Clement St., San Francisco, CA 94121, USA b Department of Orthopaedic Surgery, University of California, 500 Parnassus Ave., San Francisco, CA 94122, USA c Department of Medicine, University of California, 505 Parnassus Ave., San Francisco, CA 94122, USA |
| Abstract: | Previous work has suggested that an extracellular matrix degrading enzyme—matrix metalloproteinase-2 (MMP-2) plays an important role in the development of muscle atrophy. However, the transcriptional regulation mechanism of MMP-2 in skeletal muscle atrophy remains largely unknown. Using transgenic MMP-2 promoter reporter mice, we have demonstrated that AP-1 and RE-1 binding sites in the MMP-2 promoter region, coupled with increased binding of Fra-1, Fra-2 and AP-2, play a critical role in MMP-2 transcriptional regulation in muscle atrophy. Novel information gained from this study has improved our understanding of in vivo transcriptional regulation of MMP-2 in skeletal muscle atrophy. |
| Keywords: | Matrix metalloproteinase-2 Muscle atrophy Extracellular matrix Gene expression regulation Transcription AP-1 |
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