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KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion |
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| Authors: | Jia Li Hong-Bo Jin Yan-Ming Sun Ying Su |
| Institution: | a Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China b Department of Physiology, Harbin Medical University, Harbin 150081, China c Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China |
| Abstract: | Hyperglycemia is the major cause of diabetic angiopathy. The aim of our study was to evaluate the impact of KB-R7943, an inhibitor of Na+/Ca2+ exchanger (NCX) on cell growth and function of human “diabetic” endothelial cells (EC). Intercellular adhesion molecule-1 (ICAM-1) expression and NCX activity were determined after EC were exposed to high glucose in the absence and presence of KB-R7943. Coincubation of EC with high glucose for 24 h resulted in a significant increase of monocyte-endothelial cell adhesion and the expression of ICAM-1. These effects were abolished by KB-R7943 and KB-R7943 significantly decreased the activation of NCX induced by high glucose. These findings suggested that KB-R7943 may play a role in inhibiting expression of adhesion molecules by inhibiting the reverse activation of NCX. |
| Keywords: | Na+/Ca2+ exchanger Endothelial cell Glucose ICAM-1 Adhesion |
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