Genetics of complex disorders |
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| Authors: | Juha Kere |
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| Affiliation: | Karolinska Institutet, Department of Biosciences and Nutrition, 14157 Huddinge, Sweden Folkhälsan Institutet of Genetics, Helsinki, and Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland |
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| Abstract: | The success stories of identifying genes in Mendelian disorders have stimulated research that aims at identifying the genetic determinants in complex disorders, in which both genetics, environment and chance affect the pathogenetic processes. This review summarizes the brief history and lessons learned from genetic analysis of complex disorders and outlines some landscapes ahead for medical research. |
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| Keywords: | Gene mapping Linkage disequilibrium Genome-wide association study |
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