Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope |
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Authors: | Hua Jin Hongxia Zhao Yong Chen Shuyuan Ma Hongyan Ye |
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Affiliation: | a Chemistry Department, Jinan University, Guangzhou 510632, China b Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510090, China c The First Affiliated Hospital, Jinan University, Guangzhou 510632, China d Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330031, China |
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Abstract: | The pathophysiological changes of erythrocytes are detected at the molecular scale, which is important to reveal the onset of diseases. Type 2 diabetes is an age-related metabolic disorder with high prevalence in elderly (or old) people. Up to now, there are no treatments to cure diabetes. Therefore, early detection and the ability to monitor the progression of type 2 diabetes are very important for developing effective therapies. Type 2 diabetes is associated with high blood glucose in the context of insulin resistance and relative insulin deficiency. These abnormalities may disturb the architecture and functions of erythrocytes at molecular scale. In this study, the aging- and diabetes-induced changes in morphological and biomechanical properties of erythrocytes are clearly characterized at nanometer scale using atomic force microscope (AFM). The structural information and mechanical properties of the cell surface membranes of erythrocytes are very important indicators for determining the healthy, diseased or aging status. So, AFM may potentially be developed into a powerful tool in diagnosing diseases. |
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Keywords: | Atomic force microscope Erythrocytes Type 2 diabetes |
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