Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm |
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| Authors: | Dieter Naber Robert M Cohen David Pickar Ned H Kalin Glenn Davis Candace B Pert William E Bunney |
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| Institution: | 1. Biological Psychiatry Branch National Institute of Mental Health, Bethesda, Maryland 20205, USA;2. Clinical Neuropsychopharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205, USA |
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| Abstract: | Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity. |
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