Serotonin receptor interactions of harmaline and several related β-carbolines |
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| Authors: | Richard A Glennon |
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| Institution: | Department of Pharmaceutical Chemistry Medical College of Virginia Virginia Commonwealth University Richmond, Virginia 23298, USA |
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| Abstract: | The isolated rat fundus preparation was used to determine the serotonin (5-HT) receptor affinities (pA2 values) of harmaline, harmine and several other related β-carbolines. Replacement of a 7-methoxy group by a hydroxy group decreases affinity; the 6-methoxy β-carbolines possess two to three times the affinity of their 7-methoxy isomers. A new model is proposed for the interaction of these β-carbolines with 5-HT receptors. |
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