Developmental changes in the characteristics of peroxisomal fatty acid oxidation system in rat liver |
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Authors: | Shuichi Horie Hidemi Ishii Tetsuya Suga |
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Institution: | 1. Department of Clinical Biochemistry Tokyo College of Pharmacy 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan;1. Department of Clinical Biochemistry Faculty of Pharmaceutical Sciences Teikyo University Sagamiko-cho, Tsukui-gun, Kanagawa 199-01 Japan |
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Abstract: | Developmental changes in fatty acid oxidation system of rat liver peroxisomes were studied to compare with that of mitochondria. More apparent enhancement of peroxisomal palmitoyl-CoA oxidase was observed than mitochondrial palmitoyl-CoA dehydrogenase during prenatal (20-day fetal) to neonatal (1-day after birth) period. The characteristics of peroxisomal enzymes, fatty acyl-CoA oxidase and carnitime acyltransferase, on the bases of substrate specificities, were rapidly established within the 1 day after birth accompanied by the marked enhancement of these activities. These findings indicate that peroxisomal fatty acid oxidation system plays an important role for early growth of neonatal rats; this system may contribute to supplying short- to medium-chain fatty acyl-CoA and NADH2 for mitochondrial energy formation system. |
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