The effects of hyposmolality on spinal cord activity |
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Authors: | David A. Lake Charles D. Barnes |
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Affiliation: | Department of Physiology Texas Tech University Health Sciences Center School of Medicine Lubbock, Texas 79430, USA |
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Abstract: | The consequences of decreases in osmotic pressure were investigated using the isolated, hemisected frog spinal cord. The lateral column evoked ventral root response (LC-VRR) was depressed by a decrease in osmolality secondary to a decrease in the Na+ concentration in the bathing medium. This depression resulted from neither a depression of motoneuronal excitability nor a depression of central axonal conduction but rather from an increased excitability of lateral column terminals. The depression of the LC-VRR and augmentation of the lateral column terminal excitability were reversed by picrotoxin (10-4 M). Results are discussed in terms of the possible roles of endogenous gamma-aminobutyric acid (GABA) and extracellular K+ in the effect produced by the hyposmotic (low Na+) media. |
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Keywords: | To whom reprints should be addressed. |
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