Linkage mapping of highly informative DNA polymorphisms within the human interferon-alpha receptor gene on chromosome 21. |
| |
| Authors: | M G McInnis G Lutfalla S Slaugenhaupt M B Petersen G Uze A Chakravarti S E Antonarakis |
| |
| Affiliation: | Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. |
| |
| Abstract: | Two polymorphic loci within the interferon-alpha receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (theta = 0.02, zeta = 36.76) and D21S17 (theta = 0.02, Zeta = 21.76) with chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21. |
| |
| Keywords: | |
|
|
