Synthesis of symmetrical and unsymmetrical PAMAM dendrimers by fusion between azide- and alkyne-functionalized PAMAM dendrons |
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Authors: | Lee Jae Wook Kim Jung Hwan Kim Hee Joo Han Seung Choul Kim Ji Hyeon Shin Won Suk Jin Sung-Ho |
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Affiliation: | Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea. jlee@donga.ac.kr |
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Abstract: | A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM dendrimers in high yields. Furthermore, the coupling reactions between the different generation dendrons afford the size-differentiated unsymmetrical PAMAM dendrimers. |
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