Checkpoint signalling: Mad2 conformers and signal propagation |
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| Authors: | Hardwick Kevin G |
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| Affiliation: | Wellcome Trust Centre for Cell Biology,University of Edinburgh, Edinburgh EH93JR, UK. Kevin.Hardwick@ed.ac.uk |
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| Abstract: | The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores. |
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