Suppression of the frequencies of sister chromatid exchanges in Bloom's syndrome fibroblasts by co-cultivation with Chinese hamster cells |
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| Authors: | P P W van Buul A T Natarajan Elly A M Verdegaal-Immerzeel |
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| Institution: | (1) Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratories, Wassenaarseweg 72, Leiden, The Netherlands;(2) J. A. Cohen Institute, Interuniversity Institute for Radiopathology and Radiation Protection, The Netherlands |
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| Abstract: | Summary The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present with CHO cells, without any effect on the SCE frequency in the latter.It is suggested that possible genetic heterogeneity between different Bloom's syndrome patients can be studied using the method of co-cultivation. |
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