Design, synthesis and in vitro antitumor activity of new trans 2-[2-(heteroaryl)vinyl]-1,3-dimethylimidazolium iodides |
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Authors: | Ballistreri Francesco P Barresi Vincenza Benedetti Paolo Caltabiano Gianluigi Fortuna Cosimo G Longo Maria L Musumarra Giuseppe |
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Institution: | Dipartimento Scienze Chimiche, Università di Catania, V.le A.Doria 6, 95125, Catania, Italy. |
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Abstract: | The design, the synthesis, and the in vitro antitumor activities of trans 2-2-(heteroaryl)vinyl]-1,3-dimethylimidazolium iodides versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. The design indicates trans 2-2-5-(2-chlorophenyl)furan-2-yl]vinyl]-1, 3-dimethylimidazolium iodide 5 and trans 2-2-5-(4-bromophenyl)furan-2-yl]vinyl]-1, 3-dimethylimidazolium iodide 6 as highly active compounds in the series. The synthesis of the above new derivatives and in vitro antitumor tests, confirm their significant antiproliferative and cytotoxic activities. |
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