The Genomic Blueprint of Salmonella enterica subspecies enterica serovar Typhi P-stx-12 |
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| Authors: | Su Yean Ong Chandra Bhan Pratap Xuehua Wan Shaobin Hou Ahmad Yamin Abdul Rahman Jennifer A Saito Gopal Nath Maqsudul Alam |
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| Institution: | 1.Centre for Chemical Biology, Universiti Sains Malaysia, Penang, Malaysia;2.Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, India;3.Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii, USA |
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| Abstract: | Salmonella enterica subspecies enterica serovar Typhi is a rod-shaped, Gram-negative, facultatively anaerobic bacterium. It belongs to the family Enterobacteriaceae in the class Gammaproteobacteria, and has the capability of residing in the human gallbladder by forming a biofilm and hence causing the person to become a typhoid carrier. Here we present the complete genome of Salmonella enterica subspecies enterica serotype Typhi strain P-stx-12, which was isolated from a chronic carrier in Varanasi, India. The complete genome comprises a 4,768,352 bp chromosome with a total of 98 RNA genes, 4,691 protein-coding genes and a 181,431 bp plasmid. Genome analysis revealed that the organism is closely related to Salmonella enterica serovar Typhi strain Ty2 and Salmonella enterica serovar Typhi strain CT18, although their genome structure is slightly different. |
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| Keywords: | Enterobacteriaceae Salmonella Typhi Gram-negative host-specific pathogen Typhoid Fever |
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