Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench. |
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Authors: | L J Clifford M G Nair J Rana D L Dewitt |
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Institution: | Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA. |
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Abstract: | Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 microg/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 microg/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 microg/ml. |
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