Determination of dihydroergotamine in human plasma by high-performance liquid chromatography with fluorescence detection |
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| Authors: | Michelle Murday Angus M. McLean Elizabeth Slaughter Richard A. Couch |
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| Affiliation: | Shire Laboratories Inc., 1550 East Gude Drive, Rockville, MD 20850, USA |
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| Abstract: | Dihydroergotamine, a 5-hydroxytryptamine antagonist, is used for the treatment of vascular headaches. A high-performance liquid chromatography assay with fluorescence detection is described for the determination of dihydroergotamine in plasma. The assay was validated over the concentration range 0.1–10 ng/ml plasma and applied to the analysis of plasma samples from subjects treated intramuscularly and intranasally with 2 mg of dihydroergotamine. |
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| Keywords: | Dihydroergotamine |
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