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Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria. |
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| Authors: | G H Elder and J O Evans |
| Abstract: | Preferential rupture of the outer membrane of mitochondria from rat liver releases coproporphyrinogen oxidase in parallel with components of the intermembrane space. Coproporphyrinogen III enters the mitochondrion through the freely-permeable outer membrane. Either protoporphyrinogen IX or protoporphyrin IX must then cross the inner membrane before haem synthesis can be completed. |
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