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Mechanisms of protein folding |
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| Authors: | Ylva Ivarsson Carlo Travaglini-Allocatelli Maurizio Brunori Stefano Gianni |
| Institution: | Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Università di Roma "La Sapienza", Piazzale A. Moro 5, 00185, Rome, Italy. |
| Abstract: | Understanding the mechanism by which a polypeptide chain folds into its native structure is a central problem of modern biophysics. The collaborative efforts of experimental and theoretical studies recently raised the tantalizing possibility to define a unifying mechanism for protein folding. In this review we summarize some of these intriguing advances and analyze them together with a discussion on the new findings concerning the so-called downhill folding. |
| Keywords: | Protein folding Transition state Nucleation– condensation Diffusion– collision Folding kinetics Downhill folding |
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