Studies on 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase using chorismate mutase inhibitors |
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| Authors: | Birck M R Husain A Sheflyan G Y Ganem B Woodard R W |
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| Institution: | Department of Medicinal Chemistry, 428 Church St., University of Michigan, Ann Arbor, 48109-1065, USA. |
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| Abstract: | The proposed cyclic mechanism of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase and the mechanism of chorismate mutase share certain structural and electronic similarities. In this report, we examine several inhibitors of chorismate mutase for their efficacy against KDO 8-P synthase. |
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