Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats |
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Authors: | Suzuki Rikako Kohno Hiroyuki Murakami Akira Koshimizu Koichi Ohigashi Hajime Yano Masamichi Tokuda Harukuni Nishino Hoyoku Tanaka Takuji |
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Affiliation: | The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan. rikako@kanazawa-med.ac.jp |
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Abstract: | The inhibitory effects of dietary feeding of citrus nobiletin on azoxymethane (AOM)-induced rat colon carcinogenesis using a long-term bioassay were investigated. Five-week old male F344 rats were initiated with two weekly subcutaneous injections of AOM (20 mg/kg bw) to induce colonic tumors. They were also given the diets containing 0.01% or 0.05% nobiletin for 34 weeks, starting one week after the last dosing of AOM. At the end of the study, the incidence of colonic adenocarcinoma were 67% in the AOM alone group, 55% in the AOM-->0.01% nobiletin group, 35% (p<0.05) in the AOM-->0.05% nobiletin group. Also, nobiletin feeding reduced the cell-proliferation activity, increased the apoptotic index, and decreased the prostaglandin E2 content in colonic adenocarcinoma and/or colonic mucosa. These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis. |
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