Protection of Heme Proteins by Vitamin E, Selenium, and β-Carotene Against Oxidative Damage in Rat Heart, Kidney, Lung and Spleen |
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Authors: | H Chen A L Tappel |
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Institution: |
a Department of Food Science and Technology, University of California, Davis, CA, USA |
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Abstract: | Effects of the combination of vitamin E, selenium, and β-carotene on oxidative damage to rat heart, kidney, lung, and spleen were studied by measurement of the production of oxidized heme proteins (OHP) during spontaneous and prooxidant-induced oxidation. Male SD rats were fed with a vitamin E and selenium deficient diet or a diet supplemented with vitamin E, selenium, and β-carotene, Homogenates of heart, kidney, lung, and spleen were incubated at 37°C with and without the presence of bromotrichloromethane (CBrCl3). The diet supplemented with antioxidants showed a strong protective effect against oxidative damage to heme proteins during the early stages of both spontaneous and CBrCl3-induced oxidation in contrast to the antioxidant deficient diet. Synergism of multiple antioxygenic nutrients against oxidative damage to various animal tissues is discussed. |
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Keywords: | Heme proteins Free radicals oxidative damage Vitamin E Selenium β-carotene |
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