Oral Hepatoprotective Ability Evaluation of Purple Sweet Potato Anthocyanins on Acute and Chronic Chemical Liver Injuries |
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Authors: | Wencheng Wang Jinlian Li Zhi Wang Hui Gao Li Su Jing Xie Xuehong Chen Hui Liang Chunbo Wang Yantao Han |
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Affiliation: | 1. Medical College of Qingdao University, 308 Ningxia Road, Qingdao, 266071, Shandong, People’s Republic of China 2. Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, Shandong, People’s Republic of China 3. Qingdao University Hospital, 16 Jiangsu Road, Qingdao, 266003, Shandong, People’s Republic of China
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Abstract: | In recent years, chemical liver injury cases increased significantly in Asian countries, and the imbalance in redox system was believed to be the main cause. Purple sweet potato anthocyanins (PSPA) have been shown to exert antioxidant activity and oxidative-stress-associated functional protein modulation through various signaling pathways, so it is considered to have the potential of liver injury preventive activity. In order to evaluate the hepatoprotective potency of PSPA according to its free radical scavenging and antioxidant effects, three acute chemical liver injury models were set up with ethanol, acetaminophen and carbon tetrachloride. PSPA at moderate and high doses obviously attenuated the tested serum biomarker levels and liver index in our experiments. Besides, one chronic liver injury model set up with carbon tetrachloride was also applied, in which PSPA was orally administrated after the liver damage had been formed. Both the serum biomarker levels and histopathological analysis showed that PSPA was able to attenuated chronic liver injury. Our experimental results demonstrated the potential of PSPA as an oral hepatoprotective agent against chemical liver injury from food plant. |
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