Impaired gametogenesis in mice that overexpress the RNA-binding protein HuR |
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Authors: | Levadoux-Martin Marilyne Gouble Agnès Jégou Bernard Vallet-Erdtmann Virginie Auriol Jacques Mercier Pascale Morello Dominique |
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Affiliation: | Marilyne Levadoux-Martin, Agnès Gouble, Bernard Jégou, Virginie Vallet-Erdtmann, Jacques Auriol, Pascale Mercier, and Dominique Morello |
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Abstract: | A series of experiments, using cell culture models or in vitro assays, has shown that the RNA-binding protein HuR increases the half-life of some messenger RNAs that contain adenylate/uridylate-rich decay elements. However, its function in an integrated system has not yet been investigated. Here, using a mouse model, we report that misregulation of HuR, due to expression of an HuR transgene, prevents the production of fully functional gametes. This work provides the first evidence for a physiological function of HuR, and highlights its involvement in spermatogenesis. |
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