Fenton反应及其可能的活性产物

活性氧对许多生物分子,如脂质、蛋白质和DNA等均可引起损伤,它与许多疾病过程相联系.由超氧阴离子自由基和过氧化氢所引起的许多损伤被认为与它们转变为反应活性更强的组分有关,这些组分包括羟自由基及可能的高价铁组分.实验材料及理论结果表明,当铁盐与过氧化氢混合时,除羟自由基产生以外,高价铁组分也被认为同时产生.Fenton试剂的活性中间体是一亲核加合物,其反应活性及其产物不同于游离态羟自由基的反应活性及产物.Fenton试剂的产物分布依赖于不同的过渡金属离子、不同的配位体、不同的反应底物以及不同的溶剂基体效应.

Fenton Reaction and Its Probable Active Products

Reactive oxygen species (ROS) cause various types of damage to many biomolecules, including lipids, proteins, DNA and so on. ROS may contribute to various diseases. Much of the damage caused by superoxide anion radical and hydrogen peroxide in vivo is thought to be due to their conversion into more reactive species, including hydroxyl radical, and probable ferryl iron species. The experimental material and theoretic result have shown that in addition to generation of hydroxyl radical, the ferryl iron species have been proposed to be involved when iron salts are mixed with hydrogen peroxide. The reactive intermediate of Fenton reagents is a nucleophilic adduct. The products profiles and reactivity for Fenton reagents are different from those for free hydroxyl radical and depend upon the transition metal, the ligand, the solvent matrix and substrate.