An evaluation of the mutagenic potential of 4-chloromethylbiphenyl (4CMB) using the micronucleus test |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia;2. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O Box 80203, Jeddah 21589, Saudi Arabia;1. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32512, Egypt;2. Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar;1. Institute of Chemistry, Department of Analytical Chemistry, University of Campinas, P.O. Box 6154, 13084-971, Campinas, SP, Brazil;2. Brazilian Federal Institute, Brasília, DF, Brazil;1. AMOREPACIFIC CO/R&D Center, Gyeonggi-do 446-729, South Korea;2. School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea;3. College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea |
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| Abstract: | The micronucleus test developed by Schmid and co-workers (1970, 1971, 1973a, 1973b, 1975) is a rapid method for the screeing of chemicals for chromosome-breaking effects and has a number of advantages over other methods of chromosome analysis. Matter and Grauwiler (1974) and Bon Ledebur and Schmid (1973) showed that toxic effects of a compound on the immature nucleated cells may lead either to a reduction in cell division or to cell death. To compensate for this, normochromatic erythrocytes from the peripheral blood are shunted into the bone marrow and any increase in the ratio of normochromatic to polychromatic erythrocytes may therefore be considered indicative of toxicity. |
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