A tale of timing and transport |
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Authors: | Stell Brandon Mody Istvan |
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Affiliation: | Molecular Cellular and Integrative Physiology IDP Graduate Program, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. |
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Abstract: | Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plasticity was seen only at excitatory connections. No longer. In this issue of Neuron, Woodin et al. demonstrate that coincident pre- and postsynaptic activity acts on the neuronal K+/Cl- cotransporter KCC2 to shift the reversal potential for Cl- and thus alters the effectiveness of GABAergic synapses. |
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