Treatment of Experimental Pneumocystis carinii Pneumonia with Analogs of Pentamidine |
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| Authors: | R.R. TIDWELL S. G. KILGORE K.A. OKEMENG J.D. GERATZ JAMES EDWIN HALL |
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| Affiliation: | Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;Dcpartment of Parasitology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 |
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| Abstract: | Seven analogs of pentamidine were tested for their activity against an immunosuppressed rat model of Pneumocystis carinii pneumonia. Structural alterations of the pentamidine molecule included variations of the alkyl chain linking the two p-amidino phenoxy moieties and relocation of the amidine groups from the para to the meu position on the phenoxy rings. All analogs of pentamidine were active against P. carinii pneumonia when compared to a saline-treated control group. One derivative, 1, 4-di(4'-amidinophenoxy)butanc, proved to be statistically more active than the parent drug. |
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