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Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line
Authors:Sung Hye Youn  Choi Eun Nam  Ahn Jo Sangmee  Oh Seikwan  Ahn Jung-Hyuck
Affiliation:aDepartment of Biochemistry, School of Medicine, Ewha Womans University, 911-1 Mok-6-dong, Yangcheon-ku, Seoul 158-710, Republic of Korea;bDepartment of Neuroscience and TIDRC, School of Medicine, Ewha Womans University, 911-1 Mok-6-dong, Yangcheon-ku, Seoul 158-710, Republic of Korea;cDepartment of Pharmacy, College of Pharmacy, Dankook University, San 29 Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-714, Republic of Korea
Abstract:
Keywords:Abbreviations: 5-aza-dC, 5-aza-2&prime  -deoxycytidine   Aβ, beta amyloid   AD, Alzheimer&rsquo  s disease   APP, amyloid precursor protein   APP-sw, Swedish mutation of amyloid precursor protein   DMS, differentially methylated CpG site   MSP, methylation-specific PCR   qRT-PCR, quantitative real-time polymerase chain reaction   BSP, bisulfite sequencing PCR   CTIF, CBP80/CBP20-dependent translation initiation factor   NXT2, nuclear exporting factor 2   DDR, discoidin domain receptor   NBS, Nijmegen breakage syndrome protein
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