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Mutagenic evaluation of clonazepam using in vitro and in vivo bacterial tests. |
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| Authors: | E Matsubara M Arisawa H B Maruyama |
| Institution: | Department of Microbiology and Chemotherapy, Nippon Roche Research Center, 200 Kajiwara, Kamakura-247 Japan |
| Abstract: | The mutagenicity of an anti-epileptic drug, clonazepam, and its metabolites was studied by three repair (rec, pol and uvr) assays and reversion (Ames') tests. No detectable induction of mutation could be found in any tests by them per se or via metabolism in rat and mouse. |
| Keywords: | 2AAF 2-acetylaminofluorene CMC carboxymethylcellulose DMSO dimethyl sulfoxide HI agar heart-infusion agar MIC minimum inhibitory concentration MNNG 2NA 2-napthylamine VB agar Vogel-Bonner agar |
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