Freeze-fracture electron microscopic observations on the effects of sulphydryl group reagents on human erythrocyte membranes |
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| Authors: | G Benga A Brain V I Pop A Hodarnau J M Wrigglesworth |
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| Affiliation: | Department of Cell Biology, Faculty of Medicine, Cluj-Napoca, Roumania. |
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| Abstract: | Freeze-fracture electron microscopy of human red blood cells at pH 7.4 and 5.5 reveals the presence of membrane elevations (50-100 nm diameter). These are also observed after incubation of the erythrocytes with N-ethylmaleimide but not after incubation with p-chloromercuribenzene sulphonate. Neither of the sulphydryl-group reagents affects the distribution or size of intramembrane particles. The findings are discussed in the light of the effects of mercurials on erythrocyte membrane proteins. |
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