Neurochemical and behavioral effects of isolation-rearing in the dog |
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| Authors: | H C Agrawal M W Fox W A Himwich |
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| Affiliation: | 1. Department of Clinical Studies-Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Greece;2. Biologist, Postgraduate student, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece;3. Department of Clinical Studies-Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Greece;4. Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece;1. Institute of Chemistry, Environmental Protection and Biotechnology, Jan Dlugosz University in Czestochowa, Poland;2. Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland;3. Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Sciences, Technical University of Lodz, Poland;1. Faculty of Veterinary Medicine, University of Teramo, Teramo, 64100, Italy;2. European Center for Brain Research (CERC)/Santa Lucia Foundation IRCCS, Rome, 00143, Italy;3. Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy;4. Department of Applied Clinical and Biotechnological Sciences, University of L''Aquila, 67100, L''Aquila, Italy |
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| Abstract: | Young puppies reared in partial isolation for one week from 4–5 weeks of age showed behavioral abnormalities, being hyperactive with diffuse reactions. Significant changes also occurred in the concentration of free amino acids in the sub-cortical areas. These changes were most marked in glutamic acid and GABA, but also appeared in the glutamine and aspartic acid levels. |
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