Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum. |
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| Authors: | R Iriye K Furukawa R Nishida C Kim H Fukami |
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| Affiliation: | Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan. |
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| Abstract: | A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300 micrograms/ml. |
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