Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer |
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Authors: | Bolte Kathrin Gruenheit Nicole Felsner Gregor Sommer Maik S Maier Uwe-G Hempel Franziska |
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Institution: | Laboratory for Cell Biology, Philipps-University of Marburg, Marburg, Germany. kathrin.bolte@staff.uni-marburg.de |
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Abstract: | At first glance the three eukaryotic protein translocation machineries--the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids--appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force. Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract. |
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Keywords: | ERAD evolution of protein translocation peroxisomal importomer secondary plastid SELMA |
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