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Saturation behavior of ascites tumor cell chloride exchange in the presence of gluconate
Authors:Felice Aull
Institution:Department of Physiology and Biophysics, New York University School of Medicine, 550 First Avenue, New York, NY 10016 U.S.A.
Abstract:Steady state Cl? flux across the Ehrlich mouse ascites cell membrane was studied when gluconate replaced Cl? in the external medium. Saturation behavior was observed; K12 was 23.9 mM Cl? and V was 758 μmol · g?1 dry weight · h?1. The cells lost K+, Cl? and H2O, consistent with relative impermeability to gluconate, and the Cl? efflux rate coefficient was elevated. The results indicate that a major portion of Cl? exchange occurs as a membrane transport process and suggest that the process is sensitive to intracellular Cl? levels.
Keywords:Gluconate  Ion transport  (Ehrlich ascites cells  Michaelis-Menten kinetics)
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