Cell localization of aldolase fetal isozymes in rat regenerating liver: Differences with hepatoma

Using the indirect immunoperoxidase technique with optical and electron microscopy, we have localized both fetal aldolases A and C from regenerating rat liver in Kupffer and endothelial cells (by contrast with the localization of aldolase B in hepatocytes only). These results have been confirmed by biochemical methods. The localization of the 3 aldolases differs widely from that observed in fast-growing hepatoma and suggests that control mechanisms of gene regulation are different in cancer and in liver regeneration.