Human glomerular basement membrane. Antigenic determinants in human urine |
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Authors: | Per Bygren Jörgen Wieslander Dick Heinegård |
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Institution: | 1. Department of Nephrology, University Hospital, S-221 85 Lund Sweden;2. Department of Physiological Chemistry, University of Lund, Box 750, S-220 07 Lund Sweden |
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Abstract: | Antisera against particulate human glomerular basement membrane prepared from cadaver kidneys were raised in rabbits. It was shown that both normal individuals and patients with glomerular and tubular diseases excrete in their urine several antigens reactive with these antibodies. One antigen crossreacted immunologically with an antigen from human glomerular basement membrane while several others did not. One of the urinary antigens and the antigen crossreacting with the basement membrane were separated from the others by ion exchange chromatography and gel filtration, respectively.The pattern of antigen excretion differed depending on the underlying renal disease but the multitude of different antigens detected complicates the interpretation of the patterns of excretion in different diseases. |
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Keywords: | Urinary antigen Antigenic determinant (Glomerular basement membrane) |
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